A Review on the Chemical Constituents, Anti-inflammatory and Anti-oxidant Agents from Combretum Genus
Jude Ibeabuchi Ali
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani, Nigeria.
Felix Keneolisa Asogwa
*
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani, Nigeria.
Celestine Obiora Ugwu
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani, Nigeria.
Hannah Ndidiamaka Okorie
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani, Nigeria.
Treasure Nonye Ujam
Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani, Nigeria.
Onyeka Chinwuba Obidiegwu
Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Festus BC Okoye
Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Many diseases are treated using medicinal plants because they contain components that have therapeutic properties. The prevention and treatment of diseases linked to oxidative stress depend heavily on antioxidants. With over 20 genera and 600 species, the Combretaceae family is a vast group of plants that is distributed tropically throughout the world, with centers of diversity in Africa and Asia. In traditional medicine, certain species of Combretum are widely used as diuretics and to treat bleeding, diarrhea, infections, diabetes, malaria, and inflammation. This work is a review of Combretum species that have been assessed for their biological activity. It is imperative that more research be done on Combretum species in order to generate novel therapeutic options that could potentially enhance the well-being of individuals with a range of ailments.
Keywords: Terpenoids, flavonoids, stilbens, oxidative stress, inflammation