Plants Phenolics as Possible Pseudomonas aeruginosa Resistance Inhibitors
Asian Plant Research Journal, Volume 11, Issue 1,
Page 1-9
DOI:
10.9734/aprj/2023/v11i1200
Abstract
Pseudomonas aeruginosa virulence has for long been a serious medical, economic and social problem. It is responsible for numerous nosocomial infections like pneumonia, urinary tract infections, surgical site infections and some of community-acquired infections such as otitis, ulcerative keratitis and soft tissue infections. Its ability of adhering to various kinds of surfaces, such as hospital and surgical materials (thus: implicated in causing nosocomial infections) is one of the many reasons why P. aeruginosa is of utmost medical and economic importance. This bacterium has an extensive adaptive capability to different kinds of physical surfaces and conditions. P. aeruginosa has high capability for the formation of resistant biofilms and the regulation of efflux pumps, thus; these two contributes highly towards an elevated resistance to numerous antibiotics. Several antibiotic resistance genes are responsible for P. aeroginosa drug resistance virulence. Plant phenolics have the ability to bind to protein and non-protein domains leading to modification or inhibition protein–protein/co-factor interactions. These are a diverse group of aromatic secondary metabolites involved in plant defense. P. aeruginosa resistance genes mechanisms and evasion tactics can be affected and neutralized by ethno-plant secondary metabolites especially Phenolics, in several different ways due to the nature of its inter-molecular interactions. Ethno-plant phenolics could really provide an alternative natural remedy for the management and neutralization of P. aeruginosa Multi-drug resistance Genes.
- Phenolic
- bacteria
- genes
- efflux pumps
- resistance
How to Cite
References
Hassan AU, Madu AH, Ozojiofor UO, Galadanci AH, Mato IB, Jafaru R. Antimicrobial activities of Cymbopogon citratus and Ximenia americana leaf extracts against some selected bacterial and yeast clinical isolates. Asian Journal of Biochemistry, Genetics and Molecular Biology. 2021a;9(1):1-10.
DOI: 10.9734/AJBGMB/2021/v9i130204
Wogenie B. Effects on increasing levels of energy and protein supplementation on feed intake, body weight change and carcass composition of blackhead Somali sheep fed on grass hay. M.Sc. Thesis Presented to School of Graduate Studies, Haramaya University, Ethiopia; 2008.
Breidenstein EBM, De la Fuente-Nuñez C, Hancock REW. Pseudomonas aeruginosa: All roads lead to resistance. Trends in Microbiology A/I press Cambridge. 2011;19:419-426.
Tan TT. “Future” threat of gram-negative resistance in Singapore. Ann Academy Medical Singapore. 2008;37:884-890.
Hassan AU, Jafaru R, Mato IB, Kereakede E, Galadanci AH, Madu AH, Oyong IA, Onuh K, Ozojiofor UO. Isolation and biochemical characterization of cellulase produced by bacterial isolates from sugarcane waste soil. Asian Journal of Biochemistry, Genetics and Molecular Biology. 2021;9(2):28-35,
DOI: 10.9734/AJBGMB/2021/v9i230213
Elmouaden C, Amin L, Latifa E, Mohammed Bakkali, Mohammed Abid. Virulence genes and antibiotic resistance of Pseudomonas aeruginosa isolated from patients in the Northwestern of Morocco. Journal of Infectious. 2019;13(1):892-898.
Gomes A, Das R, Sarkhel S, Mishara R, Mukherjee S, Bhattacharya S. Herbs and herbal constituents active against snake bite. Indian Journal of Experimental Biology. 2010;48:865–878.
Habibi A, Honarmand R. Profile of virulence factors in the multi-drug resistant Pseudomonas aeruginosa strains of human Urinary Tract Infections (UTI). Iran. Red Crescent Med. J. 2015;17:e26095.
Cotar AI. Chifiriuc MC, Dinu S, Bucur M, Iordache C, Banu O, Dracea O, Larion C, Lazar V. Screening of molecular virulence markers in Staphylococcus aureus and Pseudomonas aeruginosa strains isolated from clinical infections. Int. J. Mol. Sci. 2010;11:5273–5291.
Pachori P, Gothalwal R, Gandhi P, Emergence of antibiotic resistance Pseudomonas aeruginosa in intensive care unit; A critical review. Genes Dis. 2019;6:109–119.
Galdino ACM, Branquinha MH, Santos AL, Viganor L. Pseudomonas aeruginosa and its arsenal of proteases: Weapons to battle the host. In Pathophysiological Aspects of Proteases; Chakraborti S, Dhalla N, Eds.; Springer: Singapore. 2017:381–397.
Heidary Z, Bandani E, Eftekhary M, Jafari AA. Virulence genes profile of multidrug resistant Pseudomonas aeruginosa isolated from Iranian children with UTIs. Acta Med. Iran. 2016;54:201–210.
Yousefi-Avarvand A, Khashei R, Ebrahim-Saraie HS, Emami A, Zomorodian K, Motamedifar M. The frequency of exotoxin A and exoenzymes S and U genes among clinical isolates of Pseudomonas aeruginosa in Shiraz. Iran. Int. J. Mol. Cell. Med. 2015;4:167–173.
Abba Umar H. Review: Phytochemical screening of plant extracts; 2015. Academia.edu/s/b79da63595 Online scholar’s library (www.academia.edu/researchcenter).
Elmaraghy N, Abbadi S, Elhadidi G, Hashem A, Yousef A. Virulence genes in Pseudomonas aeruginosa strains isolated at Suez Canal University Hospitals with respect to the site of infection and antimicrobial resistance. Int. J. Clin. Microbiol. Biochem. Technol. 2019;2:8–19.
Ertugrul BM, Oryasin E, Lipsky BA, Willke A, Bozdogan B. Virulence genes fliC, toxA and phzS are common among Pseudomonas aeruginosa isolates from diabetic foot infections. Infect. Dis. 2017;50:273–279.
Djordjevic ZM, Folic MM, Jankovic SM. Correlation between cefepime utilization and Pseudomonas aeruginosa resistance rate to beta lactams and carbapenems in patients with healthcare associated infections. Journal of Global Antimicrobial Resistance. 2017;13:60-64.
Nitz F, de Melo BO, da Silva LCN, de Souza Monteiro A, Marques SG, et al. Molecular detection of drug-resistance genes of blaOXA-23-blaOXA-51 and mcr-1 in clinical isolates of Pseudomonas aeruginosa. Microorganisms. 2021;9:786.
Ouyang J, Sun F, Feng W, Sun Y, Qiu X, Xiong L, et al. Quercetin is an effective inhibitor of quorum sensing, biofilm formation and virulence factors in Pseudomonas aeruginosa. J. Appl. Microbiol. 2016;120:966–974.
DOI:10.1111/jam.13073
Koulenti D, Fragkou PC, Tsiodras S. Editorial for special issue "multidrug-resistant pathogens". Microorganisms. 2020;8:1383.
Sarwat T, Rashid M, Rastogi V, Chander Y. Original research article a comparative study of antibiogram of Pseudomonas aeruginosa in hospital and community acquired infections. International Journal of Curriculum Microbiology Application Science. 2015;1:286-291.
Saak CC, Dinh CB, Dutton RJ. Experimental approaches to tracking mobile genetic elements in microbial communities. FEMS Microbiol. Rev. 2020;44:606–630.
DOI:10.1093/femsre/fuaa025
Vatan A, Saltoglu N, Yemisen M, Balkan II, Surme S, Demiray T, et al. Association between biofilm and multi/extensive drug resistance in diabetic foot infection. Int. J. Clin. Pract. 2018;72:e13060.
DOI:10.1111/ijcp.13060
Al-Dahmoshi HO. Al-Khafaji NS. Jeyad AA. Shareef HK, Al-Jebori RF. Molecular detection of some virulence traits among Pseudomonas aeruginosa isolates, Hilla-Iraq. Biomed. Pharmacol. J. 2018;11:835–842.
Mirghani ME, Liyana Y, Parveen J. Bioactivity analysis of lemon grass essential oil. International Food Research Journal. 2012;19(2):569-575.
Alain KY, Tamfu AN, Kucukaydin S, Ceylan O, Pascal AD, Félicien A, Dominique SC, Duru ME Dinica RM. Phenolic profiles, antioxidant, antiquorum sensing, antibiofilm and enzyme inhibitory activities of selected Acacia species collected from Benin. LWT. 2022;15(171):114162.
Nostro A. Activity of plant extracts and plant-derived compounds against drug-resistant microorganisms. In: Ahmad I, Aqil F, Owais M, editors. Modern phytomedicine: Turning medicinal plants into drugs. Wiley-VCH Verlag GmbH & Co. KGaA; Weinheim, Germany; 2006.
Dereli FT, Ebru ÖN, Özaydin AG, Evren AR, Muhammed MT. Persea americana Mill.: As a potent quorum sensing inhibitor of Pseudomonas aeruginosa PAO1 virulence. International Journal of Secondary Metabolite. 2022;9(1):14-26.
Bielecki P, Puchałka J, Wos-Oxley ML, Loessner H, Glik J, et al. In-Vivo expression profiling of Pseudomonas aeruginosa infections reveals niche-specific and strain-independent transcriptional programs. PLoS One. 2011;6(9):e24235.
DOI:10.1371/journal.pone.0024235
Birdi TJ, Brijesh S, Daswani PG. Bactericidal effect of selected antidiarrhoeal medicinal plants on intracellular heat-stable enterotoxin–producing Escherichia coli. Indian J Pharm Sci. 2014;79:229–235.
Vidyadhar S, Saidulu M, Gopal TK, Chamundeeswari D, Rao U. Banji D. In vitro anthelmintic activity of the whole plant of Enicostemma littorale by using various extracts. International Journal of Applied Biology and Pharmaceutical Technology. 2010;1(3):1119-1125.
Wang GS, Han J, Zhao LW, Jiang DX, Liu YT, Liu XL. Anthelmintic activity of steroidal saponins from Paris polyphylla. Phytomedicine. 2010;17:1102-1105
Anouk Z. Africa's Most Dangerous Snakes. Facts and Information about Africa's Most Venomous Snakes About.com Guide. 2010;(1):72-80.
Roopashree TS, Dang R, Rani S, Narendra C. Antibacterial activity of anti-psoriatic herbs: Cassia tora, Momordica charantia and Calendula officinalis. International Journal of Applied Research in Natural Products. 2008;1(3):20-28.
Zahara K, Panda SK, Swain SS, Luyten W. Metabolic diversity and therapeutic potential of holarrhena pubescens: An important ethnomedicinal plant. Biomolecules. 2020;10:1341.
DOI:10.3390/biom10091341
Mohammed MJ, Anand U, Altemimi AB, Tripathi V, Guo Y, Pratap-Singh A. Phenolic composition, antioxidant capacity and antibacterial activity of white wormwood (artemisia herba-alba). Plants 2021;10:164.
DOI: 10.3390/plants10010164
Hassan AU, Makeri MS, Ozojiofor UO, Alhassan AJ. Effects of Ficus sycomorus phenolic extracts on the activity of hyaluronidase and phospholipase A2 enzymes of Echis ocellatus Venom. Asian Journal of Biotechnology and Genetic Engineering. 2020;3(4):24-33.
Naik S, Mohanty S, Padhi A, Pati R, Sonawane A. Evaluation of antibacterial and cytotoxic activity of Artemisia nilagirica and Murraya koenigii leaf extracts against mycobacteria and macrophages. BMC Complement Altern Med. 2014;14:87.
Anand U, Nandy S, Mundhra A, Das N, Pandey DK, Dey A. A review on antimicrobial botanicals, phytochemicals and natural resistance modifying agents from apocynaceae family: Possible therapeutic approaches against multidrug resistance in pathogenic microorganisms. Drug Resist. 2020;51:100695.
DOI:10.1016/j.drup.2020.100695
Koh CL, Sam CK, Yin WF, Tan LY, Krishnan T, Chong YM. Plant-derived natural products as sources of anti-quorum sensing compounds. Sensors. 2013;13: 6217–6228.
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