Annona muricata (Graviola) (Annonaceae): Phytochemistry, Pharmacology and Future Directions, a Review
Patience Lunkondo Mbuyi
UR73, Development in Pedagogy and Health, Interdisciplinary Research Center of the National Pedagogical University, National Pedagogical University, Kinshasa, Democratic Republic of the Congo.
Idrissa Zabo Assumani
UR73, Development in Pedagogy and Health, Interdisciplinary Research Center of the National Pedagogical University, National Pedagogical University, Kinshasa, Democratic Republic of the Congo and Department of Biology, Faculty of Science, National Pedagogical University, Kinshasa, Democratic Republic of the Congo.
John Za Nza Ntezolo
UR73, Development in Pedagogy and Health, Interdisciplinary Research Center of the National Pedagogical University, National Pedagogical University, Kinshasa, Democratic Republic of the Congo.
Dorah Mwenyi Kabasele
UR73, Development in Pedagogy and Health, Interdisciplinary Research Center of the National Pedagogical University, National Pedagogical University, Kinshasa, Democratic Republic of the Congo.
Innocent Shongo Wale
UR73, Development in Pedagogy and Health, Interdisciplinary Research Center of the National Pedagogical University, National Pedagogical University, Kinshasa, Democratic Republic of the Congo.
Panazale Massamba
UR73, Development in Pedagogy and Health, Interdisciplinary Research Center of the National Pedagogical University, National Pedagogical University, Kinshasa, Democratic Republic of the Congo.
Victorine Mbo Lesse
UR73, Development in Pedagogy and Health, Interdisciplinary Research Center of the National Pedagogical University, National Pedagogical University, Kinshasa, Democratic Republic of the Congo.
Randy Isaya Kiala
UR73, Development in Pedagogy and Health, Interdisciplinary Research Center of the National Pedagogical University, National Pedagogical University, Kinshasa, Democratic Republic of the Congo.
Philipe Sansi Nzinga
UR73, Development in Pedagogy and Health, Interdisciplinary Research Center of the National Pedagogical University, National Pedagogical University, Kinshasa, Democratic Republic of the Congo.
Richard Mananga Bongo
UR73, Development in Pedagogy and Health, Interdisciplinary Research Center of the National Pedagogical University, National Pedagogical University, Kinshasa, Democratic Republic of the Congo.
Blaise Mbembo Wa Mbembo
Department of Biology, Faculty of Sciences, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Jean-Paul Nzambi Divengi
UR73, Development in Pedagogy and Health, Interdisciplinary Research Center of the National Pedagogical University, National Pedagogical University, Kinshasa, Democratic Republic of the Congo, Unit of Clinical Pharmacology and Pharmacology Vigilance, Department of Basic Sciences, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo and Rhumatology unite, Internal Medicine Department of General Hospital of Kinshasa Mama Yemo, Kinshasa, Democratic Republic of the Congo.
Florent Biduaya Mukeba *
Department of Biology, Faculty of Science, National Pedagogical University, Kinshasa, Democratic Republic of the Congo.
Benjamin Mbenza Longo
Unit of Clinical Pharmacology and Pharmacology Vigilance, Department of Basic Sciences, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo, Faculty of Medicine, University President Kasa-vubu, Bas-Congo, Democratic Republic of the Congo and Lomo Medical Clinic, Kinshasa, Democratic Republic of the Congo.
Mariano Manzo Lusakibanza
Unit of Clinical Pharmacology and Pharmacology Vigilance, Department of Basic Sciences, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Paulin Kapepula Mutwale
Centre d’Etudes des Substances Naturelles d’Origine Végétale (CESNOV), Faculty of Pharmaceutical Sciences, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Gauthier Kahunu Mesia
Unit of Clinical Pharmacology and Pharmacology Vigilance, Department of Basic Sciences, Faculty of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
*Author to whom correspondence should be addressed.
Abstract
Aims: Promote Annona muricata (Graviola) and provide information on its phytochemistry and bioactivity.
Study Design: Multidisciplinary advanced bibliographic surveys, utilization of ChemBioDraw software package, and dissemination of the resulted knowledge.
Place and Duration of Study: UR73, Development in Pedagogy and Health, Interdisciplinary Research Center of the National Pedagogical University, National Pedagogical University, Kinshasa, the Democratic Republic of the Congo, between June 2021 and July 2022.
Methodology: A bibliographic review was carried out to acquire information on the pharmacognosy and phytochemistry of A. muricata from various electronic databases (PubMed, PubMed Central, Science Direct and Google Scholar). The terms phytochemistry, pharmacognosy and the scientific name of this plant species were used as keywords for the search. The ChemBioDraw Ultra 15.0 software package was used to draw the chemical structures of natural compounds of A. muricata.
Results: From the results obtained, it should be noted that A. muricata is traditionally used as an analgesic or stimulant. Various studies inform that this plant has various pharmacological properties such as anti-inflammatory, antimicrobial, antihyperglycemic, antioxidant, antihelminthic, cytotoxic, antipyretic, analgesic, healing and anti-sickling effects. Many natural phytochemicals like tannins, alkaloids, phenols, glycosides, flavonoids and steroids are responsible for its properties.
Conclusion: This review therefore helps to inform future research on the design and development of new relevant drugs from A. muricata to improve human health and well-being. Especially drug candidates for the treatment of cancer and tuberculosis.
Keywords: Annona muricata, primary health care, phytoconstituents, pharmacognosy, model system